Drug interactions
Brompheniramine + Loxapine
Severity: Moderate
Brompheniramine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and brompheniramine is a sedating antihistamine with anticholinergic activity. Taken together they can cause excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects such as dry mouth, urinary retention and confusion.
What this interaction means in plain words
Brompheniramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through histamine H1 blockade and antipsychotic receptor antagonism, plus additive antimuscarinic effects.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine and watch older patients for confusion and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Loxapine?
MediHelp rates the interaction as moderate. Brompheniramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and brompheniramine is a sedating antihistamine with anticholinergic activity. Taken together they can cause excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects such as dry mouth, urinary retention and confusion.
How serious is the interaction between Brompheniramine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine and watch older patients for confusion and anticholinergic toxicity.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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