Drug interactions
Brompheniramine + Maprotiline
Severity: Moderate
Brompheniramine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system and have anticholinergic activity, so taking them together can deepen drowsiness and impair psychomotor performance. Dry mouth, urinary retention, constipation and confusion may also be more pronounced, especially in older adults.
What this interaction means in plain words
Brompheniramine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive central sedation from histamine H1 blockade and additive antimuscarinic effects.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Prefer a non-sedating antihistamine if one is needed, and watch older patients for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Maprotiline?
MediHelp rates the interaction as moderate. Brompheniramine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system and have anticholinergic activity, so taking them together can deepen drowsiness and impair psychomotor performance. Dry mouth, urinary retention, constipation and confusion may also be more pronounced, especially in older adults.
How serious is the interaction between Brompheniramine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Prefer a non-sedating antihistamine if one is needed, and watch older patients for anticholinergic effects.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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