Drug interactions
Brompheniramine + Metaxalone
Severity: Moderate
Brompheniramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine. Combined with metaxalone it can intensify drowsiness and impair performance, with higher risk in older adults.
What this interaction means in plain words
Brompheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from histamine H1 blockade and metaxalone sedation.
What to do
Monitor for oversedation, and consider a non-sedating antihistamine if appropriate. Warn patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Metaxalone?
MediHelp rates the interaction as moderate. Brompheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine. Combined with metaxalone it can intensify drowsiness and impair performance, with higher risk in older adults.
How serious is the interaction between Brompheniramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, and consider a non-sedating antihistamine if appropriate. Warn patients to avoid driving and alcohol.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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