Drug interactions
Brompheniramine + Methocarbamol
Severity: Moderate
Brompheniramine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and methocarbamol also causes drowsiness. Together they can increase sedation, dizziness and impaired concentration, and anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Brompheniramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 receptor blockade and the central effects of methocarbamol.
What to do
Advise against driving or hazardous activity and avoid alcohol. Consider a non-sedating antihistamine, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Methocarbamol?
MediHelp rates the interaction as moderate. Brompheniramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and methocarbamol also causes drowsiness. Together they can increase sedation, dizziness and impaired concentration, and anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Brompheniramine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving or hazardous activity and avoid alcohol. Consider a non-sedating antihistamine, particularly in older patients.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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