Drug interactions
Brompheniramine + Methohexital
Severity: Moderate
Brompheniramine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic. Brompheniramine may add to sedation and respiratory depression, prolonging recovery.
What this interaction means in plain words
Brompheniramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression with enhanced GABA-A activity and histamine H1 blockade.
What to do
Inform the anesthesia team about recent antihistamine use. Titrate methohexital carefully and monitor respiration and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Methohexital
Frequently asked questions
Can I take Brompheniramine with Methohexital?
MediHelp rates the interaction as moderate. Brompheniramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic. Brompheniramine may add to sedation and respiratory depression, prolonging recovery.
How serious is the interaction between Brompheniramine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about recent antihistamine use. Titrate methohexital carefully and monitor respiration and recovery.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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