Drug interactions
Brompheniramine + Nalbuphine
Severity: Moderate
Brompheniramine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and combining it with nalbuphine increases drowsiness and psychomotor impairment. Anticholinergic effects may also be troublesome in older adults.
What this interaction means in plain words
Brompheniramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and opioid receptor activity.
What to do
Consider a non-sedating antihistamine if one is needed. If the combination is used, monitor sedation and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Nalbuphine?
MediHelp rates the interaction as moderate. Brompheniramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and combining it with nalbuphine increases drowsiness and psychomotor impairment. Anticholinergic effects may also be troublesome in older adults.
How serious is the interaction between Brompheniramine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-sedating antihistamine if one is needed. If the combination is used, monitor sedation and advise against driving.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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