Drug interactions
Brompheniramine + Orphenadrin
Severity: Moderate
Brompheniramine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a first-generation antihistamine with sedative and anticholinergic properties, similar to orphenadrine. Together they can cause marked drowsiness, dry mouth, urinary retention, constipation and confusion.
What this interaction means in plain words
Brompheniramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and antimuscarinic effects.
What to do
Avoid the combination in elderly patients and those with glaucoma or urinary retention. Otherwise counsel on sedation and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Orphenadrin?
MediHelp rates the interaction as moderate. Brompheniramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a first-generation antihistamine with sedative and anticholinergic properties, similar to orphenadrine. Together they can cause marked drowsiness, dry mouth, urinary retention, constipation and confusion.
How serious is the interaction between Brompheniramine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in elderly patients and those with glaucoma or urinary retention. Otherwise counsel on sedation and consider a non-sedating antihistamine.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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