Drug interactions
Brompheniramine + Oxymorphone
Severity: Moderate
Brompheniramine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines add to opioid-induced drowsiness and may impair alertness and coordination. Anticholinergic effects can also worsen constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and H1-receptor blockade with central sedative effects.
What to do
Counsel patients to avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Oxymorphone?
MediHelp rates the interaction as moderate. Brompheniramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines add to opioid-induced drowsiness and may impair alertness and coordination. Anticholinergic effects can also worsen constipation and urinary retention.
How serious is the interaction between Brompheniramine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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