Drug interactions
Brompheniramine + Ramelteon
Severity: Moderate
Brompheniramine and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and combined use with ramelteon may increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Brompheniramine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depression via histamine H1 blockade and melatonin receptor agonism.
What to do
Counsel on additive sedation and avoid driving or hazardous tasks. Consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Ramelteon?
MediHelp rates the interaction as moderate. Brompheniramine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and combined use with ramelteon may increase drowsiness and impair psychomotor performance.
How serious is the interaction between Brompheniramine and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving or hazardous tasks. Consider a non-sedating antihistamine if needed.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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