Drug interactions
Brompheniramine + Thioridazine
Severity: Moderate
Brompheniramine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have sedative and anticholinergic properties. Combining them can cause excess drowsiness, confusion, dry mouth, urinary retention and constipation, particularly in older adults. Impaired psychomotor performance raises the risk of falls and accidents.
What this interaction means in plain words
Brompheniramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive histamine H1 blockade and muscarinic antagonism producing CNS depression and anticholinergic effects.
What to do
Avoid combining where possible, especially in elderly patients, and choose a non-sedating antihistamine if one is needed. If used together, monitor for sedation and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Thioridazine?
MediHelp rates the interaction as moderate. Brompheniramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have sedative and anticholinergic properties. Combining them can cause excess drowsiness, confusion, dry mouth, urinary retention and constipation, particularly in older adults. Impaired psychomotor performance raises the risk of falls and accidents.
How serious is the interaction between Brompheniramine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in elderly patients, and choose a non-sedating antihistamine if one is needed. If used together, monitor for sedation and anticholinergic toxicity.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
