Drug interactions
Budesonide + Crofelemer
Severity: Minor
Budesonide and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. A small increase in oral budesonide exposure is theoretically possible, but a clinically important effect is unlikely.
What this interaction means in plain words
Budesonide and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible local intestinal CYP3A4 inhibition by crofelemer.
What to do
No routine adjustment is needed; be aware of possible increased corticosteroid effects with oral budesonide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Budesonide with Crofelemer?
MediHelp rates the interaction as minor. Budesonide and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. A small increase in oral budesonide exposure is theoretically possible, but a clinically important effect is unlikely.
How serious is the interaction between Budesonide and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware of possible increased corticosteroid effects with oral budesonide.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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