Drug interactions
Crofelemer + Ergotamine
Severity: Moderate
Crofelemer and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut. A clinically significant increase in ergotamine exposure is possible but uncertain, and ergotamine toxicity causes serious vasospasm.
What this interaction means in plain words
Crofelemer and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crofelemer belongs to Gastrointestinal Tract; Ergotamine belongs to Central Nervous System.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer reducing ergotamine first-pass metabolism; not well established.
What to do
Monitor for ergotism signs such as paresthesia, cold extremities and nausea. Use the lowest effective ergotamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Crofelemer
Frequently asked questions
Can I take Crofelemer with Ergotamine?
MediHelp rates the interaction as moderate. Crofelemer and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut. A clinically significant increase in ergotamine exposure is possible but uncertain, and ergotamine toxicity causes serious vasospasm.
How serious is the interaction between Crofelemer and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism signs such as paresthesia, cold extremities and nausea. Use the lowest effective ergotamine dose.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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