Drug interactions
Aprepitant + Crofelemer
Severity: Minor
Aprepitant and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed, so its effects on CYP3A4 are limited to the gut and are unlikely to alter aprepitant exposure meaningfully. Clinical impact is probably small.
What this interaction means in plain words
Aprepitant and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Crofelemer may inhibit intestinal CYP3A4 locally, possibly slightly raising aprepitant absorption.
What to do
No dose adjustment is needed. Be aware of increased aprepitant adverse effects if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Crofelemer
Frequently asked questions
Can I take Aprepitant with Crofelemer?
MediHelp rates the interaction as minor. Aprepitant and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed, so its effects on CYP3A4 are limited to the gut and are unlikely to alter aprepitant exposure meaningfully. Clinical impact is probably small.
How serious is the interaction between Aprepitant and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of increased aprepitant adverse effects if they occur.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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