Drug interactions
Armodafinil + Crofelemer
Severity: Minor
Armodafinil and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut. A clinically relevant rise in armodafinil exposure is not expected.
What this interaction means in plain words
Armodafinil and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with negligible systemic effect.
What to do
No action is generally required beyond awareness. Monitor for increased armodafinil adverse effects such as headache or insomnia if they arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Crofelemer
Frequently asked questions
Can I take Armodafinil with Crofelemer?
MediHelp rates the interaction as minor. Armodafinil and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut. A clinically relevant rise in armodafinil exposure is not expected.
How serious is the interaction between Armodafinil and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required beyond awareness. Monitor for increased armodafinil adverse effects such as headache or insomnia if they arise.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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