Drug interactions
Apixaban + Crofelemer
Severity: Minor
Apixaban and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and could inhibit CYP3A4 only in the gut. A meaningful effect on apixaban is unlikely.
What this interaction means in plain words
Apixaban and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apixaban belongs to Cardiovascular; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible intestinal CYP3A4 inhibition, with little systemic exposure to crofelemer.
What to do
No routine action is needed; be aware of the theoretical effect if unexpected bleeding occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Crofelemer
Frequently asked questions
Can I take Apixaban with Crofelemer?
MediHelp rates the interaction as minor. Apixaban and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and could inhibit CYP3A4 only in the gut. A meaningful effect on apixaban is unlikely.
How serious is the interaction between Apixaban and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of the theoretical effect if unexpected bleeding occurs.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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