Drug interactions
Budesonide + Fedratinib
Severity: Moderate
Budesonide and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 moderately and may raise budesonide exposure, particularly with oral budesonide that depends on extensive first-pass metabolism. This increases the risk of systemic corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Budesonide and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of budesonide.
What to do
Monitor for signs of corticosteroid excess such as Cushingoid features and hypercortisolism, and use the lowest effective budesonide dose. Consider an alternative corticosteroid if prolonged co-therapy is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Budesonide with Fedratinib?
MediHelp rates the interaction as moderate. Budesonide and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 moderately and may raise budesonide exposure, particularly with oral budesonide that depends on extensive first-pass metabolism. This increases the risk of systemic corticosteroid effects such as adrenal suppression.
How serious is the interaction between Budesonide and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as Cushingoid features and hypercortisolism, and use the lowest effective budesonide dose. Consider an alternative corticosteroid if prolonged co-therapy is required.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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