Drug interactions
Budesonide + Fluconazole
Severity: Moderate
Budesonide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and can raise budesonide concentrations, increasing systemic corticosteroid exposure. This may lead to Cushingoid features and adrenal suppression, especially with prolonged use or higher fluconazole doses.
What this interaction means in plain words
Budesonide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated budesonide metabolism by fluconazole reduces first-pass and systemic clearance.
What to do
Monitor for signs of corticosteroid excess during prolonged co-use and consider reducing the budesonide dose. Avoid prolonged combination when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Budesonide with Fluconazole?
MediHelp rates the interaction as moderate. Budesonide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and can raise budesonide concentrations, increasing systemic corticosteroid exposure. This may lead to Cushingoid features and adrenal suppression, especially with prolonged use or higher fluconazole doses.
How serious is the interaction between Budesonide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during prolonged co-use and consider reducing the budesonide dose. Avoid prolonged combination when possible.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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