Drug interactions
Budesonide + Hydrochlorothiazide-irbesartan
Severity: Minor
Budesonide and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic glucocorticoid exposure from budesonide can add to the potassium loss caused by hydrochlorothiazide. Risk is greater with oral or high-dose therapy than with inhaled or topical use.
What this interaction means in plain words
Budesonide and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide and glucocorticoid mineralocorticoid effects.
What to do
Monitor serum potassium when systemic budesonide is used long-term with the thiazide. Replace potassium if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Budesonide and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic glucocorticoid exposure from budesonide can add to the potassium loss caused by hydrochlorothiazide. Risk is greater with oral or high-dose therapy than with inhaled or topical use.
How serious is the interaction between Budesonide and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when systemic budesonide is used long-term with the thiazide. Replace potassium if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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