Drug interactions
Budesonide + Hydrochlorothiazide
Severity: Minor
Budesonide and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium. Budesonide has some mineralocorticoid activity, and systemic exposure is greater with oral formulations, high doses or CYP3A4 inhibition. Combined use may add to potassium loss and raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Budesonide and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic potassium wasting from thiazide diuresis and glucocorticoid mineralocorticoid effect.
What to do
Check serum potassium and magnesium when starting the combination or after dose changes, especially with oral or high-dose budesonide. Replace potassium if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Budesonide with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Budesonide and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can lower serum potassium. Budesonide has some mineralocorticoid activity, and systemic exposure is greater with oral formulations, high doses or CYP3A4 inhibition. Combined use may add to potassium loss and raise arrhythmia risk in susceptible patients.
How serious is the interaction between Budesonide and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium when starting the combination or after dose changes, especially with oral or high-dose budesonide. Replace potassium if levels fall.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
