Drug interactions
Budesonide + Methylprednisolone
Severity: Moderate
Budesonide and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two corticosteroids gives additive glucocorticoid effects and systemic adverse effects such as adrenal suppression, hyperglycemia and infection risk. Pharmacokinetic interaction between them is not clinically significant.
What this interaction means in plain words
Budesonide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Methylprednisolone belongs to Endocrine.
Why it happens
Additive glucocorticoid pharmacodynamic effects; both are CYP3A4 substrates.
What to do
Avoid unnecessary duplication of corticosteroid therapy and account for total glucocorticoid exposure. Monitor glucose, blood pressure and signs of adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Methylprednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Methylprednisolone?
MediHelp rates the interaction as moderate. Budesonide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two corticosteroids gives additive glucocorticoid effects and systemic adverse effects such as adrenal suppression, hyperglycemia and infection risk. Pharmacokinetic interaction between them is not clinically significant.
How serious is the interaction between Budesonide and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of corticosteroid therapy and account for total glucocorticoid exposure. Monitor glucose, blood pressure and signs of adrenal suppression.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
