Drug interactions
Budesonide + Nevirapine
Severity: Moderate
Budesonide and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower budesonide concentrations, potentially reducing its local or systemic anti-inflammatory efficacy. The effect is most relevant for oral budesonide used in intestinal disease.
What this interaction means in plain words
Budesonide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolism of budesonide.
What to do
Monitor for loss of budesonide effectiveness and increase the dose or choose an alternative if symptoms of the underlying disease recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Budesonide with Nevirapine?
MediHelp rates the interaction as moderate. Budesonide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower budesonide concentrations, potentially reducing its local or systemic anti-inflammatory efficacy. The effect is most relevant for oral budesonide used in intestinal disease.
How serious is the interaction between Budesonide and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of budesonide effectiveness and increase the dose or choose an alternative if symptoms of the underlying disease recur.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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