Drug interactions
Budesonide-formoterol + Desipramine
Severity: Major
Budesonide-formoterol and Desipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine carries a recognised risk of QT prolongation and arrhythmia, and formoterol can add to the effect on cardiac repolarisation and heart rate. Tricyclics may also potentiate cardiovascular responses to beta-agonists.
What this interaction means in plain words
Budesonide-formoterol and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Desipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and adrenergic stimulation, with tricyclic potentiation of sympathomimetic effects.
What to do
Check baseline ECG and potassium and magnesium. Monitor QTc and heart rate, and consider an alternative antidepressant or bronchodilator if risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Desipramine?
MediHelp rates the interaction as major. Budesonide-formoterol and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Desipramine carries a recognised risk of QT prolongation and arrhythmia, and formoterol can add to the effect on cardiac repolarisation and heart rate. Tricyclics may also potentiate cardiovascular responses to beta-agonists.
How serious is the interaction between Budesonide-formoterol and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium and magnesium. Monitor QTc and heart rate, and consider an alternative antidepressant or bronchodilator if risk factors are present.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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