Drug interactions
Budesonide-formoterol + Fluoxetine
Severity: Moderate
Budesonide-formoterol and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and formoterol may potentiate this and cause tachycardia. Risk increases with hypokalemia, high doses or cardiac disease.
What this interaction means in plain words
Budesonide-formoterol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with beta2-agonist hypokalemia as a contributor.
What to do
Check ECG and electrolytes in patients with QT risk factors. Do not exceed the labeled formoterol dose and correct potassium or magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Fluoxetine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and formoterol may potentiate this and cause tachycardia. Risk increases with hypokalemia, high doses or cardiac disease.
How serious is the interaction between Budesonide-formoterol and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with QT risk factors. Do not exceed the labeled formoterol dose and correct potassium or magnesium deficits.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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