Drug interactions
Budesonide-formoterol + Histrelin
Severity: Moderate
Budesonide-formoterol and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation. Formoterol may add to QT effects, increasing the possibility of torsades de pointes in susceptible patients.
What this interaction means in plain words
Budesonide-formoterol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation.
What to do
Consider ECG and electrolyte monitoring in patients with cardiac risk factors or congenital long QT. Correct hypokalemia before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Budesonide-formoterol with Histrelin?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation. Formoterol may add to QT effects, increasing the possibility of torsades de pointes in susceptible patients.
How serious is the interaction between Budesonide-formoterol and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG and electrolyte monitoring in patients with cardiac risk factors or congenital long QT. Correct hypokalemia before and during treatment.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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