Drug interactions
Budesonide-formoterol + Ibutilide
Severity: Major
Budesonide-formoterol and Ibutilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs repolarization and carries a substantial risk of torsades de pointes. Formoterol can add to QT prolongation and lower potassium, further raising that risk.
What this interaction means in plain words
Budesonide-formoterol and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Ibutilide belongs to Cardiovascular.
Why it happens
Additive QTc prolongation and beta-agonist related hypokalemia increasing proarrhythmic susceptibility.
What to do
Avoid giving formoterol around ibutilide infusion where possible, correct potassium and magnesium beforehand, and monitor ECG continuously during and after administration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Ibutilide?
MediHelp rates the interaction as major. Budesonide-formoterol and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide markedly prolongs repolarization and carries a substantial risk of torsades de pointes. Formoterol can add to QT prolongation and lower potassium, further raising that risk.
How serious is the interaction between Budesonide-formoterol and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving formoterol around ibutilide infusion where possible, correct potassium and magnesium beforehand, and monitor ECG continuously during and after administration.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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