Drug interactions
Budesonide-formoterol + Lapatinib
Severity: Moderate
Budesonide-formoterol and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and formoterol may add to QTc prolongation and raise heart rate. Hypokalemia increases the risk.
What this interaction means in plain words
Budesonide-formoterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Lapatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation, with beta2-agonist hypokalemia contributing.
What to do
Obtain baseline ECG and correct electrolytes before combining. Repeat ECG if symptoms such as palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Budesonide-formoterol with Lapatinib?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and formoterol may add to QTc prolongation and raise heart rate. Hypokalemia increases the risk.
How serious is the interaction between Budesonide-formoterol and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct electrolytes before combining. Repeat ECG if symptoms such as palpitations or syncope occur.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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