Drug interactions
Budesonide-formoterol + Mifepristone
Severity: Major
Budesonide-formoterol and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval and can cause hypokalemia. Formoterol adds QTc and potassium-lowering effects, increasing arrhythmia risk.
What this interaction means in plain words
Budesonide-formoterol and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation, with hypokalemia from mifepristone-related mineralocorticoid effects and beta2-agonism.
What to do
Prefer an alternative bronchodilator if possible; otherwise monitor ECG and serum potassium and correct deficits promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Mifepristone?
MediHelp rates the interaction as major. Budesonide-formoterol and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval and can cause hypokalemia. Formoterol adds QTc and potassium-lowering effects, increasing arrhythmia risk.
How serious is the interaction between Budesonide-formoterol and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative bronchodilator if possible; otherwise monitor ECG and serum potassium and correct deficits promptly.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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