Drug interactions
Budesonide-formoterol + Nebivolol
Severity: Moderate
Budesonide-formoterol and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can antagonize the bronchodilating effect of formoterol and may trigger bronchospasm in people with asthma or COPD. Nebivolol is highly beta-1 selective, so the risk is lower than with nonselective drugs, but selectivity is lost at higher doses.
What this interaction means in plain words
Budesonide-formoterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, limited by the beta-1 selectivity of nebivolol.
What to do
Use the lowest effective nebivolol dose and monitor respiratory symptoms and peak flow. Reassess the combination if airway symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Budesonide-formoterol with Nebivolol?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can antagonize the bronchodilating effect of formoterol and may trigger bronchospasm in people with asthma or COPD. Nebivolol is highly beta-1 selective, so the risk is lower than with nonselective drugs, but selectivity is lost at higher doses.
How serious is the interaction between Budesonide-formoterol and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor respiratory symptoms and peak flow. Reassess the combination if airway symptoms worsen.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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