Drug interactions
Budesonide-formoterol + Quizartinib
Severity: Major
Budesonide-formoterol and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and can cause torsades de pointes. Formoterol can add a small QT effect and lower potassium, which may increase this risk.
What this interaction means in plain words
Budesonide-formoterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalaemia increasing arrhythmia susceptibility.
What to do
Monitor ECG more often and keep potassium and magnesium within normal range. Consider an alternative to formoterol if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Budesonide-formoterol with Quizartinib?
MediHelp rates the interaction as major. Budesonide-formoterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and can cause torsades de pointes. Formoterol can add a small QT effect and lower potassium, which may increase this risk.
How serious is the interaction between Budesonide-formoterol and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more often and keep potassium and magnesium within normal range. Consider an alternative to formoterol if QTc becomes significantly prolonged.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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