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Drug interactions

Budesonide-formoterol + Thioridazine

Severity: Major

Budesonide-formoterol and Thioridazine: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Thioridazine is strongly associated with QT prolongation and torsades de pointes. Formoterol can contribute through hypokalemia and tachycardia, further raising the risk of serious ventricular arrhythmia.

What this interaction means in plain words

Budesonide-formoterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Budesonide-formoterol belongs to Respiratory; Thioridazine belongs to Central Nervous System.

Evidence level: Moderate

Why it happens

Additive QT prolongation with formoterol-induced hypokalemia and increased heart rate.

What to do

Avoid the combination where possible; if used, check ECG and correct potassium and magnesium before and during therapy.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Budesonide-formoterol with Thioridazine?

MediHelp rates the interaction as major. Budesonide-formoterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine is strongly associated with QT prolongation and torsades de pointes. Formoterol can contribute through hypokalemia and tachycardia, further raising the risk of serious ventricular arrhythmia.

How serious is the interaction between Budesonide-formoterol and Thioridazine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, check ECG and correct potassium and magnesium before and during therapy.

What other medicines interact with Budesonide-formoterol?

MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.

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