Drug interactions
Bumetanide + Captopril
Severity: Moderate
Bumetanide and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding captopril to a loop diuretic can cause marked first-dose hypotension, particularly in volume-depleted patients, and may reduce renal function.
What this interaction means in plain words
Bumetanide and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Captopril belongs to Cardiovascular.
Why it happens
Additive hemodynamic effects: diuretic volume depletion increases dependence on angiotensin II, which ACE inhibition blocks.
What to do
Start captopril at a low dose, consider temporarily reducing bumetanide, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Bumetanide with Captopril?
MediHelp rates the interaction as moderate. Bumetanide and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding captopril to a loop diuretic can cause marked first-dose hypotension, particularly in volume-depleted patients, and may reduce renal function.
How serious is the interaction between Bumetanide and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start captopril at a low dose, consider temporarily reducing bumetanide, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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