Drug interactions
Bumetanide + Citalopram
Severity: Moderate
Bumetanide and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both loop diuretics and SSRIs such as citalopram can lower serum sodium, so combined use increases the risk of hyponatremia, especially in older adults. Loop-diuretic-induced hypokalemia and hypomagnesemia may also add to citalopram QT risk.
What this interaction means in plain words
Bumetanide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
Additive hyponatremia via diuretic sodium loss and SSRI-associated SIADH, plus electrolyte-mediated QT risk.
What to do
Check sodium, potassium and magnesium at baseline and after initiation, particularly in elderly patients. Correct electrolytes and consider ECG monitoring if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Bumetanide with Citalopram?
MediHelp rates the interaction as moderate. Bumetanide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both loop diuretics and SSRIs such as citalopram can lower serum sodium, so combined use increases the risk of hyponatremia, especially in older adults. Loop-diuretic-induced hypokalemia and hypomagnesemia may also add to citalopram QT risk.
How serious is the interaction between Bumetanide and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sodium, potassium and magnesium at baseline and after initiation, particularly in elderly patients. Correct electrolytes and consider ECG monitoring if QT risk factors are present.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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