Drug interactions
Bumetanide + Cortisone
Severity: Moderate
Bumetanide and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity that promotes potassium excretion and sodium retention, adding to the potassium loss from bumetanide. Hypokalemia may be more pronounced with prolonged or high-dose therapy.
What this interaction means in plain words
Bumetanide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium wasting from corticosteroid mineralocorticoid effects and loop diuretic kaliuresis.
What to do
Monitor serum potassium and blood pressure, and supplement potassium as needed during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Cortisone?
MediHelp rates the interaction as moderate. Bumetanide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity that promotes potassium excretion and sodium retention, adding to the potassium loss from bumetanide. Hypokalemia may be more pronounced with prolonged or high-dose therapy.
How serious is the interaction between Bumetanide and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and supplement potassium as needed during combined use.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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