Drug interactions
Bumetanide + Dichlorphenamide
Severity: Moderate
Bumetanide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so together they can cause significant hypokalemia and metabolic disturbance. Dichlorphenamide also causes metabolic acidosis, which may complicate electrolyte management.
What this interaction means in plain words
Bumetanide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from loop diuretic action and carbonic anhydrase inhibition.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bumetanide and Dichlorphenamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bumetanide
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Bumetanide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Bumetanide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so together they can cause significant hypokalemia and metabolic disturbance. Dichlorphenamide also causes metabolic acidosis, which may complicate electrolyte management.
How serious is the interaction between Bumetanide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
