Drug interactions
Bumetanide + Enalapril
Severity: Moderate
Bumetanide and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic, especially in a volume-depleted patient, can cause marked first-dose hypotension and acute deterioration of renal function. The risk is highest at initiation or after a dose increase.
What this interaction means in plain words
Bumetanide and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Enalapril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion activates the renin-angiotensin system, and ACE inhibition removes efferent arteriolar tone, lowering blood pressure and glomerular filtration.
What to do
Consider temporarily reducing or holding the diuretic before starting enalapril and begin with a low dose. Check blood pressure, creatinine and potassium within 1 to 2 weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bumetanide and Enalapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bumetanide
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Bumetanide with Enalapril?
MediHelp rates the interaction as moderate. Bumetanide and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic, especially in a volume-depleted patient, can cause marked first-dose hypotension and acute deterioration of renal function. The risk is highest at initiation or after a dose increase.
How serious is the interaction between Bumetanide and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily reducing or holding the diuretic before starting enalapril and begin with a low dose. Check blood pressure, creatinine and potassium within 1 to 2 weeks.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
