Drug interactions
Bumetanide + Fenoprofen
Severity: Moderate
Bumetanide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can blunt the diuretic and natriuretic response to bumetanide. In patients with heart failure, cirrhosis or renal impairment this may cause fluid retention and kidney function decline.
What this interaction means in plain words
Bumetanide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, counteracting loop diuretic effect.
What to do
Monitor weight, edema, blood pressure and renal function, and raise the diuretic dose if the response is reduced. Limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Fenoprofen?
MediHelp rates the interaction as moderate. Bumetanide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can blunt the diuretic and natriuretic response to bumetanide. In patients with heart failure, cirrhosis or renal impairment this may cause fluid retention and kidney function decline.
How serious is the interaction between Bumetanide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and raise the diuretic dose if the response is reduced. Limit NSAID duration.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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