Drug interactions
Bumetanide + Fentanyl
Severity: Minor
Bumetanide and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may reduce the response to a loop diuretic. The effect is generally modest and variable.
What this interaction means in plain words
Bumetanide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bumetanide belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-induced antidiuretic hormone release and urinary retention may counteract diuretic effect.
What to do
Monitor urine output, weight and fluid status. Adjust the bumetanide dose if the diuretic response falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Fentanyl?
MediHelp rates the interaction as minor. Bumetanide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may reduce the response to a loop diuretic. The effect is generally modest and variable.
How serious is the interaction between Bumetanide and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight and fluid status. Adjust the bumetanide dose if the diuretic response falls.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
