Drug interactions
Bumetanide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Bumetanide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding bumetanide to a thiazide-containing product produces strong additive diuresis, with risk of hypokalemia, hypomagnesemia, hyponatremia, volume depletion and hypotension. Olmesartan may reduce potassium loss but increases renal function risk with volume depletion.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Sequential nephron blockade by loop and thiazide diuretics produces additive natriuresis and electrolyte loss.
What to do
Monitor electrolytes, creatinine, weight and blood pressure within the first weeks and after dose changes. Replace potassium and magnesium as needed and reduce diuretic doses if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding bumetanide to a thiazide-containing product produces strong additive diuresis, with risk of hypokalemia, hypomagnesemia, hyponatremia, volume depletion and hypotension. Olmesartan may reduce potassium loss but increases renal function risk with volume depletion.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure within the first weeks and after dose changes. Replace potassium and magnesium as needed and reduce diuretic doses if volume depletion develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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