Drug interactions
Bumetanide + Ketorolac
Severity: Moderate
Bumetanide and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the diuretic and natriuretic response to bumetanide. Concurrent use also raises the risk of nephrotoxicity, especially in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and loop diuretic delivery and effect, and cause sodium retention.
What to do
Monitor urine output, weight, volume status and renal function. Avoid the combination in dehydrated patients and keep ketorolac duration short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Ketorolac?
MediHelp rates the interaction as moderate. Bumetanide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can reduce the diuretic and natriuretic response to bumetanide. Concurrent use also raises the risk of nephrotoxicity, especially in volume-depleted patients.
How serious is the interaction between Bumetanide and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight, volume status and renal function. Avoid the combination in dehydrated patients and keep ketorolac duration short.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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