Drug interactions
Bumetanide + Magnesium sulfate
Severity: Minor
Bumetanide and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide increases urinary magnesium excretion and can lower serum magnesium, partly offsetting magnesium sulfate given for repletion. Hypomagnesemia can also aggravate loop diuretic-related potassium loss and arrhythmia risk.
What this interaction means in plain words
Bumetanide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of the Na-K-2Cl cotransporter in the thick ascending limb reduces magnesium reabsorption, increasing renal loss.
What to do
Monitor serum magnesium and potassium and adjust magnesium dosing to the measured levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Magnesium sulfate?
MediHelp rates the interaction as minor. Bumetanide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bumetanide increases urinary magnesium excretion and can lower serum magnesium, partly offsetting magnesium sulfate given for repletion. Hypomagnesemia can also aggravate loop diuretic-related potassium loss and arrhythmia risk.
How serious is the interaction between Bumetanide and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium and adjust magnesium dosing to the measured levels.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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