Drug interactions
Bumetanide + Metaproterenol
Severity: Moderate
Bumetanide and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol is a beta-2 agonist that can lower serum potassium, and bumetanide causes renal potassium loss. Combined, they may produce significant hypokalemia and increase arrhythmia risk.
What this interaction means in plain words
Bumetanide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated cellular potassium uptake plus loop diuretic kaliuresis.
What to do
Monitor serum potassium, particularly with high-dose or oral metaproterenol. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Metaproterenol?
MediHelp rates the interaction as moderate. Bumetanide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol is a beta-2 agonist that can lower serum potassium, and bumetanide causes renal potassium loss. Combined, they may produce significant hypokalemia and increase arrhythmia risk.
How serious is the interaction between Bumetanide and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with high-dose or oral metaproterenol. Supplement potassium if needed.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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