Drug interactions
Bumetanide + Neomycin po
Severity: Moderate
Bumetanide and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics and aminoglycosides both injure the cochlea and kidney. Oral neomycin is poorly absorbed, but absorption can rise with damaged gut mucosa or renal impairment, increasing risk.
What this interaction means in plain words
Bumetanide and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic-related volume depletion increasing renal vulnerability.
What to do
Avoid in renal impairment or inflamed bowel and with prolonged use; otherwise monitor renal function and hearing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Neomycin po?
MediHelp rates the interaction as moderate. Bumetanide and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics and aminoglycosides both injure the cochlea and kidney. Oral neomycin is poorly absorbed, but absorption can rise with damaged gut mucosa or renal impairment, increasing risk.
How serious is the interaction between Bumetanide and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in renal impairment or inflamed bowel and with prolonged use; otherwise monitor renal function and hearing.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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