Drug interactions
Bumetanide + Parecoxib
Severity: Moderate
Bumetanide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can reduce the diuretic and antihypertensive effects of loop diuretics. The combination also raises the risk of acute kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, opposing loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function during combined use. Use the lowest effective parecoxib dose for the shortest time and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Parecoxib?
MediHelp rates the interaction as moderate. Bumetanide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can reduce the diuretic and antihypertensive effects of loop diuretics. The combination also raises the risk of acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Bumetanide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function during combined use. Use the lowest effective parecoxib dose for the shortest time and ensure adequate hydration.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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