Drug interactions
Bumetanide + Quinapril
Severity: Moderate
Bumetanide and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor, particularly in volume-depleted patients, can cause marked first-dose hypotension and a decline in renal function. The combination is common and useful in heart failure but needs careful initiation.
What this interaction means in plain words
Bumetanide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: diuretic volume depletion plus ACE inhibitor reduction of angiotensin II-mediated efferent arteriolar tone.
What to do
Consider reducing or temporarily holding the bumetanide dose before starting quinapril in volume-depleted patients. Check blood pressure, creatinine and potassium within the first one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Quinapril?
MediHelp rates the interaction as moderate. Bumetanide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor, particularly in volume-depleted patients, can cause marked first-dose hypotension and a decline in renal function. The combination is common and useful in heart failure but needs careful initiation.
How serious is the interaction between Bumetanide and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding the bumetanide dose before starting quinapril in volume-depleted patients. Check blood pressure, creatinine and potassium within the first one to two weeks.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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