Drug interactions
Bumetanide + Sacubitril / valsartan
Severity: Moderate
Bumetanide and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan can raise potassium while bumetanide lowers it, so the net effect varies. Together they also increase the risk of hypotension and reduced renal function, particularly with volume depletion.
What this interaction means in plain words
Bumetanide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing potassium effects (angiotensin receptor blockade vs renal potassium loss) and additive hypotensive and volume-depleting effects.
What to do
Monitor potassium, creatinine and blood pressure after starting or changing doses. Reduce the diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Bumetanide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan can raise potassium while bumetanide lowers it, so the net effect varies. Together they also increase the risk of hypotension and reduced renal function, particularly with volume depletion.
How serious is the interaction between Bumetanide and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, creatinine and blood pressure after starting or changing doses. Reduce the diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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