Drug interactions
Bumetanide + Salicylates
Severity: Moderate
Bumetanide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can reduce the diuretic effect of loop diuretics and may affect renal function, especially at higher doses. Salicylate clearance may also be reduced, increasing salicylate toxicity risk in high-dose use.
What this interaction means in plain words
Bumetanide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition causes sodium retention and reduced renal blood flow, and loop diuretics compete for renal tubular secretion with salicylates.
What to do
Monitor diuretic response, weight and renal function. Use the lowest effective salicylate dose and watch for signs of salicylate toxicity such as tinnitus at high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Salicylates?
MediHelp rates the interaction as moderate. Bumetanide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can reduce the diuretic effect of loop diuretics and may affect renal function, especially at higher doses. Salicylate clearance may also be reduced, increasing salicylate toxicity risk in high-dose use.
How serious is the interaction between Bumetanide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight and renal function. Use the lowest effective salicylate dose and watch for signs of salicylate toxicity such as tinnitus at high doses.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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