Drug interactions
Bumetanide + Salsalate
Severity: Moderate
Bumetanide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate NSAID, may blunt the diuretic and antihypertensive effect of bumetanide. It can also contribute to renal impairment in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis leads to sodium and water retention and reduced renal perfusion.
What to do
Monitor weight, edema, blood pressure and renal function during combined use. Increase the bumetanide dose if needed or choose a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Salsalate?
MediHelp rates the interaction as moderate. Bumetanide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate NSAID, may blunt the diuretic and antihypertensive effect of bumetanide. It can also contribute to renal impairment in volume-depleted patients.
How serious is the interaction between Bumetanide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function during combined use. Increase the bumetanide dose if needed or choose a non-NSAID analgesic.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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