Drug interactions
Bumetanide + Telmisartan
Severity: Moderate
Bumetanide and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an angiotensin receptor blocker to a loop diuretic can cause excessive blood pressure reduction and a decline in renal function, particularly when the patient is volume depleted. Potassium effects are opposing, so serum levels may be unpredictable.
What this interaction means in plain words
Bumetanide and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Additive hemodynamic effects of volume depletion from the diuretic and efferent arteriolar dilation from angiotensin receptor blockade; opposing effects on potassium.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing the diuretic dose or starting telmisartan at a low dose in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Bumetanide with Telmisartan?
MediHelp rates the interaction as moderate. Bumetanide and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an angiotensin receptor blocker to a loop diuretic can cause excessive blood pressure reduction and a decline in renal function, particularly when the patient is volume depleted. Potassium effects are opposing, so serum levels may be unpredictable.
How serious is the interaction between Bumetanide and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing the diuretic dose or starting telmisartan at a low dose in volume-depleted patients.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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