Drug interactions
Bumetanide + Terbutaline
Severity: Moderate
Bumetanide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum potassium, so combined use can cause clinically significant hypokalemia. This increases the risk of cardiac arrhythmias and muscle weakness, especially in patients with heart disease or on digoxin.
What this interaction means in plain words
Bumetanide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 agonism shifts potassium into cells while the loop diuretic increases renal potassium excretion.
What to do
Monitor serum potassium and magnesium, particularly at the start of therapy or with high terbutaline doses. Give potassium supplementation as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Terbutaline?
MediHelp rates the interaction as moderate. Bumetanide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum potassium, so combined use can cause clinically significant hypokalemia. This increases the risk of cardiac arrhythmias and muscle weakness, especially in patients with heart disease or on digoxin.
How serious is the interaction between Bumetanide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at the start of therapy or with high terbutaline doses. Give potassium supplementation as needed.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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