Drug interactions
Bumetanide + Tobramycin inhaled
Severity: Moderate
Bumetanide and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics add to the ototoxic and nephrotoxic potential of aminoglycosides, and volume depletion can raise aminoglycoside exposure. Systemic absorption from inhaled tobramycin is low, so the risk is smaller than with injection but not absent, especially in renal impairment.
What this interaction means in plain words
Bumetanide and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic volume depletion possibly increasing aminoglycoside concentrations.
What to do
Monitor renal function, hearing symptoms and hydration status. Check serum tobramycin levels if renal impairment or ototoxic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Bumetanide and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics add to the ototoxic and nephrotoxic potential of aminoglycosides, and volume depletion can raise aminoglycoside exposure. Systemic absorption from inhaled tobramycin is low, so the risk is smaller than with injection but not absent, especially in renal impairment.
How serious is the interaction between Bumetanide and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hearing symptoms and hydration status. Check serum tobramycin levels if renal impairment or ototoxic symptoms develop.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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